489446-83-5Relevant academic research and scientific papers
Synthesis and DNA binding properties of saturated distamycin analogues
Woods, Craig R.,Faucher, Nicolas,Eschgfaller, Bernd,Bair, Kenneth W.,Boger, Dale L.
, p. 2647 - 2650 (2002)
A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C50 values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.
