Bioorganic and Medicinal Chemistry Letters p. 2647 - 2650 (2002)
Update date:2022-08-04
Topics: -Synthesis -DNA binding -Analogues
Woods, Craig R.
Faucher, Nicolas
Eschgfaller, Bernd
Bair, Kenneth W.
Boger, Dale L.
A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C50 values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.
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Doi:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2
(2002)Doi:10.1016/S0040-4039(01)96127-1
(1973)Doi:10.1016/j.bmcl.2009.04.124
(2009)Doi:10.1016/S0040-4039(00)79810-8
(1973)Doi:10.1016/j.jcat.2021.02.027
(2021)Doi:10.1021/ja01179a010
(1949)
