489453-08-9

Upstream product

• 646-03-7 3-aminopropanenitrile hydrochloride 
• 803706-19-6 (2S,4R)-4-({(2S,4R)-1-Benzyloxycarbonyl-4-[((2S,4R)-1-benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-2-carbonyl}-amino)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 489453-07-8 (2S,4R)-4-({(2S,4R)-1-Benzyloxycarbonyl-4-[((2S,4R)-1-benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-2-carbonyl}-amino)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 489453-06-7 (2S,4R)-4-[((2S,4R)-1-Benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1212395-57-7 methyl (2S,4R)-4-amino-1-[benzyloxycarbonyl]pyrrolidine-2-carboxylate hydrochloride 
• 189215-90-5 1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate 
• 489446-81-3 (2R,4S)-4-tert-Butoxycarbonylamino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 393524-17-9 (2S,4R)-4-tert-Butoxycarbonylamino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 

Downstream Products

• 489447-25-8 C₄₃H₅₁N₉O₁₀ 

Relevant academic research and scientific papers

Synthesis and DNA binding properties of saturated distamycin analogues

A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C50 values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.