489455-66-5Relevant academic research and scientific papers
A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides
Chen, Zhengwang,Liang, Pei,Liu, Botao,Luo, Haiqing,Zheng, Jing,Wen, Xiaowei,Liu, Tanggao,Ye, Min
, p. 8481 - 8485 (2018/11/27)
A new tandem decyanation/cyanation reaction of α-iminonitriles has been developed. A variety of cyano-substituted aryl amides and heteroaryl amides are synthesized in good yields. Both electron-rich and electron-deficient groups are compatible with the standard conditions. This reaction features a nonmetallic cyano source, tandem decyanation and cyanation reaction, waste utilization of the HCN from the hydrolysis of α-iminonitriles, formation of two important functional groups in one-step operation, etc.
