515152-78-0Relevant academic research and scientific papers
Negishi cross-couplings compatible with unprotected amide functions
Manolikakes, Georg,Dong, Zhibing,Mayr, Herbert,Li, Jinshan,Knochel, Paul
supporting information; experimental part, p. 1324 - 1328 (2009/09/04)
The reaction conditions that allow a general Pd-catalyzed Negishi cross-coupling of a functionalized alkyl, aryl, heteroaryl, and benzylic zinc reagents with aryl acidic hydrogens were investigated. A dry and argon flushed 10 mL Schlenk-tube was charged with N-benzyl-4-bromobenzamide, Pd(OAc) 2, S-PHOS, and THF. 3-pentanoyl-benzylzinc chloride was added slowly over 90 minutes with a syringe pump. The reaction mixture was stirred for 1 hour at 25 °C. The reaction mixture was quenched with a saturated NH 4Cl solution and extracted with diethyl ether. The combined phases were then washed with a aqueous thiourea solution and dried over Na 2SO4. It was observed that the mild conditions considerably increase the ability of the Negishi cross-coupling in the synthesis of complex molecules and natural products.
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR
Angell, Richard M.,Angell, Tony D.,Bamborough, Paul,Brown, David,Brown, Murray,Buckton, Jacky B.,Cockerill, Stuart G.,Edwards, Chris D.,Jones, Katherine L.,Longstaff, Tim,Smee, Penny A.,Smith, Kathryn J.,Somers, Don O.,Walker, Ann L.,Willson, Malcolm
, p. 324 - 328 (2008/12/22)
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38α are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.
