489475-05-0Relevant academic research and scientific papers
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) antitumor agents
Antonow, Dyeison,Kaliszczak, MacIej,Kang, Gyoung-Dong,Coffils, Marissa,Tiberghien, Arnaud C.,Cooper, Nectaroula,Barata, Teresa,Heidelberger, Sibylle,James, Colin H.,Zloh, Mire,Jenkins, Terence C.,Reszka, Anthony P.,Neidle, Stephen,Guichard, Sylvie M.,Jodrell, Duncan I.,Hartley, John A.,Howard, Philip W.,Thurston, David E.
supporting information; experimental part, p. 2927 - 2941 (2010/09/14)
A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and
Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents
Cooper, Nectaroula,Hagan, David R.,Tiberghien, Arnaud,Ademefun, Temitope,Matthews, Charles S.,Howard, Philip W.,Thurston, David E.
, p. 1764 - 1765 (2007/10/03)
Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.
