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Electroauxiliary-assisted sequential introduction of two carbon nucleophiles on the same α-carbon of nitrogen: Application to the synthesis of spiro compounds
Suga, Seiji,Watanabe, Mitsuru,Yoshida, Jun-ichi
, p. 14824 - 14825 (2002)
The sequential introduction of two carbon nucleophiles on the same α-carbon of nitrogen by using selective oxidative cleavage of two silyl groups as electroauxilialies has been accomplished. The combination of this expedient transformation and ring-closing metathesis enables reliable and straightforward syntheses of nitrogen-containing spiro compounds, such as cephalotaxine. Copyright
