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Diethyl 2-(2-hydroxybenzyl)malonate is an organic compound with the chemical formula C16H18O6. It is a white crystalline solid that is soluble in organic solvents. diethyl 2-(2-hydroxybenzyl)malonate is a derivative of malonic acid, featuring a benzyl group attached to the malonate core, with a hydroxyl group on the benzene ring. It is synthesized through a series of chemical reactions, often involving the condensation of malonic acid with a substituted benzyl halide in the presence of a base. Diethyl 2-(2-hydroxybenzyl)malonate is used as an intermediate in the synthesis of various pharmaceuticals and other organic compounds, particularly in the preparation of certain drugs and agrochemicals. Its structure and reactivity make it a valuable building block in organic synthesis, allowing for the creation of a wide range of complex molecules.

4895-96-9

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4895-96-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4895-96-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,9 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4895-96:
(6*4)+(5*8)+(4*9)+(3*5)+(2*9)+(1*6)=139
139 % 10 = 9
So 4895-96-9 is a valid CAS Registry Number.

4895-96-9Downstream Products

4895-96-9Relevant academic research and scientific papers

Michael additions of highly basic enolates to ortho -quinone methides

Lewis, Robert S.,Garza, Christopher J.,Dang, Ann T.,Pedro, Te Kie A.,Chain, William J.

, p. 2278 - 2281 (2015/05/13)

A protocol by which ketone or ester enolates and ortho-quinone methides (o-QMs) are generated in situ in a single reaction flask from silylated precursors under the action of anhydrous fluoride is reported. The reaction partners are joined to give a variety of β-(2-hydroxyphenyl)-carbonyl compounds in 32-94% yield in a single laboratory operation. The intermediacy of o-QMs is supported by control experiments utilizing enolate precursors and conventional alkyl halides as competitive alkylating agents and the isolation of 1,5-dicarbonyl products resulting from conjugate additions that do not restore the aromatic system.

Mild and rapid method for the generation of ortho -(naphtho)quinone methide intermediates

Shaikh, Abdul Kadar,Cobb, Alexander J. A.,Varvounis, George

, p. 584 - 587 (2012/03/10)

A new mild method has been devised for generating o-(naphtho)quinone methides via fluoride-induced desilylation of silyl derivatives of o-hydroxybenzyl(or 1-naphthylmethyl) nitrate. The reactive o-(naphtho)quinone methide intermediates were trapped by C,

REACTIVITY OF NEW PRECURSORS OF QUINONE METHIDES

Loubinoux, Bernard,Miazimbakana, Joseph,Gerardin, Philippe

, p. 1939 - 1942 (2007/10/02)

The azidomethylene protecting group allows the synthesis of unstable phenolic compounds which are used as quinone methide precursors in the alkylations of alcohols, phenols, azide, thiophenol, amines, enols and enolates.

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