490-18-6

Usage

Uses

Used in Pharmaceutical Industry:
(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 serves as a key component in the development of pharmaceuticals, leveraging its unique structure to enhance drug efficacy and target specific biological pathways.
Used in Polymer Synthesis:
In the field of polymer chemistry, (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 acts as a crucial building block, contributing to the creation of novel polymers with tailored properties for various applications.
Used as a Chemical Intermediate:
(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 is utilized as an intermediate in the synthesis of other complex organic compounds, facilitating the production of a wide range of chemical products.

Upstream product

• 7400-08-0 p-Coumaric Acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1428579-86-5 (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid 

Downstream Products

• 36650-53-0 dimethyl 4,4'-dimethoxy-α-truxillate 
• 133098-91-6 C₃₀H₄₈O₆Si₄ 
• 40493-54-7 4,4'-Dimethoxy-α-truxillsaeure 
• 40493-49-0 p,p'-Dimethoxy-α-truxillsaeure-dichlorid 
• 75456-19-8 [3-Carboxymethyl-2,4-bis-(4-methoxy-phenyl)-cyclobutyl]-acetic acid 
• 75456-18-7 1α,3β-bis(carbomethoxymethyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane 
• 75456-17-6 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane 

Relevant academic research and scientific papers

Anti-inflammatory activities of α-truxillic acid derivatives and their monomer components

The anti-inflammatory activities of α-truxillic acid (1) and 4,4′-dihydroxy-α-truxillic acid (2) as well as their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) were evaluated in the formalin test. α-Truxillic acid (1) and its deriva

Divaccinosides A–D, four rare iridoid glucosidic truxillate esters from the leaves of Vaccinium bracteatum

Divaccinosides A–D (1–4), four rare iridoid glucoside cyclodimers in the truxillate forms, were characterized from the leaves of Vaccinium bracteatum. They were presumably biosynthesized from two known iridoid glucoside monomers, vaccinoside (5) and 10-O-trans-p-coumaroyl-6α-hydroxyl-dihydromonotropein (6), via a [2+2] cycloaddition reaction. The structures of the new compounds were established by comprehensive spectroscopic measurements, combined with chemical conversions and single crystal X-ray crystallographic analyses.

Remarkably high homoselectivity in [2 + 2] photodimerization of: Trans -cinnamic acids in multicomponent systems

[2 + 2] homoadducts were exclusively obtained with total regio- and stereo-selectivities when a suspension of several solid photoactive trans-cinnamic acids in cyclohexane was stirred and irradiated.

Inhibitory effect of 4,4′-dihydroxy-α-truxillic acid derivatives on NO production in lipopolysaccharide-induced RAW 264.7 macrophages and exploration of structure-activity relationships

The inhibitory activity of 4,4′-dihydroxy-α-truxillic acid and its derivatives (5-1a-5-35a) on nitric oxide (NO) release was evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds 5-3a, 5-4a, 5-5a, 5-10a, 5-24a, 5-26a and 5-30a exhibited significant inhibitory effects on NO production, with IC50 values of 19.8, 21.1, 16.4, 17.5, 20.8, 22.6 and 17.6 μM, respectively. Their cytotoxicities were also estimated using a CCK-8 assay. Among them, compound 5-10a showed no cytotoxic effect on cells up to a concentration of 50 μM. The structure-activity relationships of the compounds are also discussed.

Templating photodimerization of trans-cinnamic acids with cucurbit[8]uril and γ-cyclodextrin

(Chemical Equation Presented) Cucurbit[8]uril and γ-cyclodextrin are able to align two olefin molecules in a head-head fashion within their large cavities. Excitation of such templated olefins results in syn head-head cyclobutanes in nearly quantitative yields. The methodology revealed here works with trans-cinnamic acids that do not dimerize either in solution or in the solid state and with the ones that yield only anti head-tail dimer in the solid state.