4900-18-9Relevant academic research and scientific papers
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors
Quan, Mimi L.,Wong, Pancras C.,Wang, Cailan,Woerner, Francis,Smallheer, Joanne M.,Barbera, Frank A.,Bozarth, Jeffrey M.,Brown, Randi L.,Harpel, Mark R.,Luettgen, Joseph M.,Morin, Paul E.,Peterson, Tara,Ramamurthy, Vidhyashankar,Rendina, Alan R.,Rossi, Karen A.,Watson, Carol A.,Wei, Anzhi,Zhang, Ge,Seiffert, Dietmar,Wexler, Ruth R.
, p. 955 - 969 (2014/03/21)
Antithrombotic agents that are inhibitors of factor XIa (FXIa) have the potential to demonstrate robust efficacy with a low bleeding risk profile. Herein, we describe a series of tetrahydroquinoline (THQ) derivatives as FXIa inhibitors. Compound 1 was ide
TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS
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Page 86, (2008/06/13)
The present invention provides compounds of Formula (I) ; or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4/su
