4906-68-7 Usage
Uses
Used in Pharmaceutical Industry:
3-bromo-5-phenyl Salicylic Acid is used as a selective inhibitor for the AKR1C1 enzyme, which plays a role in the metabolism of progesterone and has been implicated in cancer and neuroactive steroid processing. Its high selectivity and potency in inhibiting AKR1C1 (Ki = 4 nM) over other AKR1C enzymes make it a valuable tool for studying the function and role of this enzyme in various biological processes.
Used in Cancer Research:
3-bromo-5-phenyl Salicylic Acid is used as a potential therapeutic agent in cancer research, particularly in the context of AKR1C1's involvement in cancer progression. By selectively inhibiting AKR1C1, 3-bromo-5-phenyl Salicylic Acid may help to modulate the metabolic pathways associated with cancer cell growth and survival, offering a potential avenue for the development of targeted cancer therapies.
Used in Neurobiology and Brain Function Studies:
Due to its role in the processing of neuroactive steroids involved in brain function, 3-bromo-5-phenyl Salicylic Acid is used as a research tool to investigate the impact of AKR1C1 inhibition on neurobiological processes. This may lead to a better understanding of the enzyme's role in neurological disorders and the development of novel treatments for such conditions.
Used in Endothelial Cell Research:
3-bromo-5-phenyl Salicylic Acid is used to study the metabolism of progesterone in bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM). This application helps researchers understand the enzyme's function in the context of progesterone metabolism and its potential implications for reproductive health and other related physiological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 4906-68-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,0 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4906-68:
(6*4)+(5*9)+(4*0)+(3*6)+(2*6)+(1*8)=107
107 % 10 = 7
So 4906-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
4906-68-7Relevant academic research and scientific papers
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20α-hydroxysteroid dehydrogenase (AKR1C1)
El-Kabbani, Ossama,Scammells, Peter J.,Gosling, Joshua,Dhagat, Urmi,Endo, Satoshi,Matsunaga, Toshiyuki,Soda, Midori,Hara, Akira
experimental part, p. 3259 - 3264 (2010/06/16)
The first design, synthesis, and evaluation of human 20α- hydroxysteroid dehydrogenase (AKR1C1) inhibitors based on the recently published crystal structure of its ternary complex with inhibitor are reported. While the enzyme-inhibitor interactions observ
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs
Shrestha, Suja,Bhattarai, Bharat Raj,Lee, Keun-Hyeung,Cho, Hyeongjin
, p. 6535 - 6548 (2008/04/12)
A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those derivatives, 3c exhibited about a 14-fold selectivity against TC-PTP, and this compound was tested in a mouse model for its efficacy to prevent diet-induced obesity. It effectively suppressed the increases in body weight and adipose mass, without any noticeable toxic effect. The compound also prevented increases in the plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations; thus, expanding its therapeutic potential to other related metabolic diseases, such as hyperlipidemia and hypercholesterolemia.
