4910-26-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl N-[(phenylsulfanyl)carbonyl]glycinate is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical properties and potential in the development of new drugs and bioactive compounds.
Used in Agrochemical Industry:
Ethyl N-[(phenylsulfanyl)carbonyl]glycinate is used as a building block for the preparation of agrochemicals, contributing to the development of effective and innovative products in agriculture.
Used in Organic Synthesis:
Ethyl N-[(phenylsulfanyl)carbonyl]glycinate is used as a versatile intermediate in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications.
Used in Antimicrobial Applications:
Ethyl N-[(phenylsulfanyl)carbonyl]glycinate is studied for its potential antimicrobial properties, offering a promising avenue for the development of new antimicrobial agents.
Used in Anti-inflammatory Applications:
Ethyl N-[(phenylsulfanyl)carbonyl]glycinate is investigated for its potential anti-inflammatory properties, which could lead to the development of novel anti-inflammatory drugs.

Upstream product

• 13464-19-2 phenyl chlorothioformate 
• 459-73-4 GlyOEt*HCl 
• 2999-46-4 Ethyl isocyanoacetate 
• 80-17-1 benzenesufonyl hydrazide 
• 98-09-9 benzenesulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 108-98-5 thiophenol 
• 108-86-1 bromobenzene 
• 62076-10-2 (tert-butylsulfinyl)benzene 

Downstream Products

• 411212-95-8 N-phenylsulfanylcarbonyl-glycine-(N'-benzyloxycarbonyl-hydrazide) 
• 100616-49-7 N-(N-phenylsulfanylcarbonyl-glycyl)-alanine methyl ester 
• 109368-21-0 N-(N-benzyloxycarbonyl-glycyl)-N,N'-carbonyl-bis-glycine 
• 21639-45-2 N-phenylsulfanylcarbonyl-glycine 

Relevant academic research and scientific papers

Metal-Free Catalytic Synthesis of Thiocarbamates Using Sodium Sulfinates as the Sulfur Source

A novel molecular iodine-catalyzed protocol for the construction of thiocarbamates from readily available sodium sulfinates, isocyanides, and water has been described. The present methodology offers a facile and practical route to a variety of thiocarbamates in moderate to good yields with favorable functional group tolerance by use odorless sodium sulfinates as the sulfur source. The mechanistic studies suggest the present transformation involves a radical process.

Visible-Light-Enabled Construction of Thiocarbamates from Isocyanides, Thiols, and Water at Room Temperature

A convenient visible-light-induced method for the synthesis of thiocarbamates from isocyanides, thiols, and water has been developed under mild reaction conditions. The present protocol offers a cost-effective and operationally straightforward approach to the various thiocarbamates in moderate to good yields by simple use of cheap Rose Bengal as the photocatalyst and water as the reaction reagent as well as an environmentally benign cosolvent.

Clean preparation of S-thiocarbamates with in situ generated hydroxide in 2-methyltetrahydrofuran

A simple and clean protocol for the synthesis of various alkyl and (hetero)aryl S-thiocarbamates was established. The usage of in situ generated hydroxide as both an oxygen source and hydrogen source as well as biomass-derived 2-methyltetrahydrofuran as a

Electrosynthesis of: S -thiocarbamates with disulfides as a sulfur source

An electrochemical oxidative synthesis of S-thiocarbamates by a carbamothioation reaction via a three-component coupling reaction (disulfide, water and isocyanide) is developed, which avoids the use of external oxidants and generates only hydrogen gas as the by-product. With NH4I as the mediator and electrolyte, the desired S-thiocarbamates were obtained in good yields in an undivided cell at room temperature.

Iodine-Catalyzed Odorless Synthesis of S-Thiocarbamates with Sulfonyl Chlorides as a Sulfur Source

A general and efficient protocol for the direct preparation of various S-thiocarbamates with readily available and inexpensive sulfonyl chlorides as an odorless sulfur source was developed. The employment of easily available reactants, excellent functiona

Preparation method of thiocarbamate compound

The invention belongs to the field of synthesis of a compound, relates to a preparation method of a thiocarbamate compound, in particular to a method for synthesizing thiocarbamate through reacting ofcatalyzing three components of sodium sulfinate, isonitrile and water by iodine. The method comprises the following steps: adding the sodium sulfinate, the isonitrile and the water into ethyl acetate, then adding a molecular iodine catalyst and a phosphite reducing agent, heating, stirring and reacting for 6 to 10 hours under a condition that the temperature is 80 to 100 DEG C, and extracting, separating and purifying after finishing the reaction, thus obtaining the thiocarbamate. According to the method disclosed by the invention, the isonitrile is adopted as a carbon source, so that poisonous photogene and carbon monoxide are prevented from being used; odorless sodium sulfinate is adopted as a sulfur source, so that odorous thiophenol or thiol is prevented from being used; non-metalliciodine is adopted for catalyzing, so that a metal reagent is prevented from being used; the reaction has the advantages that the operation is simple and convenient, the technology is safe, environmentfriendliness is realized, and the like.

Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds

Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.