4915-06-4

Basic information

• Product Name: 5-broMo-2-furonitrile
• Synonyms: 5-broMo-2-furonitrile
• CAS NO: 4915-06-4
• Molecular Formula: C₅H₂BrNO
• Molecular Weight: 171.97948
• Mol File: 4915-06-4.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-broMo-2-furonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-2-furonitrile(4915-06-4)
• EPA Substance Registry System: 5-broMo-2-furonitrile(4915-06-4)

Safety Data

• Hazardous Substances Data: 4915-06-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-furonitrile is a chemical compound with the molecular formula C5H3BrNO2. It is a brominated furan derivative, which is a five-membered heterocyclic ring containing both oxygen and nitrogen atoms. 5-broMo-2-furonitrile is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It has been reported as an important intermediate for the synthesis of pyrimidines, which are essential components in various drugs and biologically active compounds. Its versatile reactivity and functional groups make it a valuable starting material for the development of new chemical entities with potential pharmacological and agricultural applications.

Upstream product

• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 6134-61-8 5-bromo-furan-2-carboxylic acid amide 
• 4465-70-7 5-bromofurfural (E)-oxime 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 67-56-1 methanol 

Downstream Products

• 2639446-16-3 5-(dimethylphosphoryl)furan-2-carbonitrile 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents

Phidianidines (1), isolated from the marine opisthobranch mollusk Phidiana militaris, present the first example of natural products possessing an 1,2,4-oxadiazole ring system and show various bioactivities. However, the structure-activity relationship stu

IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidinyl carboxamide compounds described herein include substituted 2-heterocyclyl-4-alkyl-imidazo[1,5-a]pyrirnidine-8-carboxamide compounds and variants thereof.

Electrocatalytic synthesis of nitriles from aldehydes with ammonium acetate as the nitrogen source

A simple synthesis method of nitriles from corresponding aldehydes by electrochemical oxidation was developed with ammonium acetate as the nitrogen source and 4-acetamido- 2,2,6,6-tetramethylpiperidinyl-l-oxy (4-AcNH-TEMPO) as the catalyst. Cyclic voltammetry was performed to investigate the electrocatalytic activity of 4-AcNH-TEMPO for the conversion of benzaldehyde to benzonitrile. On the basis of in situ FTIR data and cyclic voltammetry experiments, a reaction mechanism, involving the redox of 4-AcNH-TEMPO and the generation of intermediate imine during the reaction, was proposed. This electrocatalytic reaction system provided an efficient protocol for synthesis of aromatic nitriles at room temperature with moderate to high yields.