491572-04-4

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 4-(3,4-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, methyl ester
• CAS NO: 491572-04-4
• Molecular Formula: C23H25NO7
• Molecular Weight: 427.454
• Mol File: 491572-04-4.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,4-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,4-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, methyl ester(491572-04-4)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 4-(3,4-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, methyl ester(491572-04-4)

Safety Data

• Hazardous Substances Data: 491572-04-4(Hazardous Substances Data)

Upstream product

• 39687-95-1 isocyanoacetic acid methyl ester 
• 4460-86-0 asaraldehyde 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 491572-06-6 4-(3,4-dimethoxyphenyl)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(2,4,5-trimethoxyphenyl)-1H-pyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

An effective synthesis of α-cyanoenamines by Peterson olefination

A convenient and gentle method for the synthesis of α-cyanoenamines based on the Peterson olefination has been developed. For these sensitive, highly functionalized olefins, the present method is superior to the Horner-Emmons condensation, as manifested by the higher yields and broader scope.

Regioselective preparation of 2-substituted 3,4-diaryl pyrroles: A concise total synthesis of ningalin B

Methylisocyanoacetate undergoes a 2 + 3 cycloaddition with α,β-unsaturated nitriles to provide a regioselective synthesis of 2-substituted 3,4-diaryl pyrroles. The ease of preparation of α,β-unsaturated nitriles allows the rapid synthesis of pyrroles with varied substituents. Using this method, a key intermediate (1) for the synthesis of the marine natural products lukianol A, lamellarin O, and lamellarin Q was prepared in two steps. A total synthesis of ningalin B (11) was also accomplished utilizing this methodology.