491589-44-7Relevant academic research and scientific papers
Highly Stereoselective Synthesis of syn-1,3-Diols through a Sequential Titanium-Mediated Aldol Reaction and LiBH4 Reduction
Esteve, Judit,Matas, Sonia,Pellicena, Miquel,Velasco, Javier,Romea, Pedro,Urpi, Felix,Font-Bardia, Merce
experimental part, p. 3146 - 3151 (2010/08/20)
A sequential transformation based on a titanium-mediated aldol reaction from chiral α-tert-butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH4 provides a straightforward, access to syn-1,3-diols. These diols, containing up to three new stereocentres, can be easily isolated in high yields after a simple work-up without any additional oxidative treatment, which confers to this procedure an appealing position to prepare stereoselectively such sort of structures.
Stereoselective synthesis of syn,syn-2-methyl-1,3-diols through one-pot aldol-reduction sequence
Galobardes, Marta,Mena, Marisa,Romea, Pedro,Urpí, Fèlix,Vilarrasa, Jaume
, p. 6145 - 6148 (2007/10/03)
Chx2BCl-mediated syn-aldol reaction of the α-OTBS lactate-derived ketone 1 followed by in situ reduction of the resulting boron aldolate with LiBH4 lead to complete stereoselectivity for the boronates 2 in 80-95% yields. Then, a very
