491845-97-7Relevant academic research and scientific papers
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl] -2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin su
Ye, Zhixiong,Guo, Liangqin,Barakat, Khaled J.,Pollard, Patrick G.,Palucki, Brenda L.,Sebhat, Iyassu K.,Bakshi, Raman K.,Tang, Rui,Kalyani, Rubana N.,Vongs, Aurawan,Chen, Airu S.,Chen, Howard Y.,Rosenblum, Charles I.,MacNeil, Tanya,Weinberg, David H.,Peng, Qianping,Tamvakopoulos, Constantin,Miller, Randy R.,Stearns, Ralph A.,Cashen, Doreen E.,Martin, William J.,Metzger, Joseph M.,Strack, Alison M.,MacIntyre, D. Euan,Van Der Ploeg, Lex H. T.,Patchett, Arthur A.,Wyvratt, Matthew J.,Nargund, Ravi P.
, p. 3501 - 3505 (2005)
A novel isoquinuclidine containing selective melanocortin subtype-4 receptor small molecule agonist, 3 (RY764), is reported. Its in vivo characterization revealed mechanism-based food intake reduction and erectile activity augmentation in rodents.
