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1-(2-Thiazolyl)piperazine dihydrochloride, commonly referred to as ThPP dihydrochloride, is a significant chemical compound with a wide range of pharmaceutical and scientific applications. It serves as a fundamental building block in organic synthesis, particularly in the preparation of bioactive molecules. As a dihydrochloride salt, it exhibits high solubility in water, making it suitable for use in aqueous solutions. ThPP dihydrochloride is also a key component in the development of certain antipsychotic and antidepressant medications, contributing to its importance in pharmaceutical research and development.

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  • 492431-13-7 Structure
  • Basic information

    1. Product Name: 1-(2-Thiazolyl)piperazine dihydrochloride
    2. Synonyms: 1-(2-Thiazolyl)piperazine dihydrochloride
    3. CAS NO:492431-13-7
    4. Molecular Formula: C7H13Cl2N3S
    5. Molecular Weight: 242.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 492431-13-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 355.7 °C at 760 mmHg
    3. Flash Point: 168.9 °C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 2.15E-05mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1-(2-Thiazolyl)piperazine dihydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(2-Thiazolyl)piperazine dihydrochloride(492431-13-7)
    12. EPA Substance Registry System: 1-(2-Thiazolyl)piperazine dihydrochloride(492431-13-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 492431-13-7(Hazardous Substances Data)

492431-13-7 Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Thiazolyl)piperazine dihydrochloride is used as a building block in the synthesis of bioactive molecules for the development of new drugs. Its versatile properties make it a valuable component in the creation of antipsychotic and antidepressant medications, enhancing their efficacy and therapeutic potential.
Used in Scientific Research:
1-(2-Thiazolyl)piperazine dihydrochloride is used as a research compound in various scientific studies, particularly in the fields of organic chemistry and medicinal chemistry. Its role in the preparation of bioactive molecules allows researchers to explore new avenues in drug discovery and development, as well as to understand the underlying mechanisms of action for existing medications.

Check Digit Verification of cas no

The CAS Registry Mumber 492431-13-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,2,4,3 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 492431-13:
(8*4)+(7*9)+(6*2)+(5*4)+(4*3)+(3*1)+(2*1)+(1*3)=147
147 % 10 = 7
So 492431-13-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H11N3S.2ClH/c1-4-10(5-2-8-1)7-9-3-6-11-7;;/h3,6,8H,1-2,4-5H2;2*1H

492431-13-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-piperazin-1-yl-1,3-thiazole,dihydrochloride

1.2 Other means of identification

Product number -
Other names 2-piperazin-1-yl-1,3-thiazole dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:492431-13-7 SDS

492431-13-7Downstream Products

492431-13-7Relevant articles and documents

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

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Page/Page column 39, (2010/02/08)

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

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