474417-23-7

Basic information

• Product Name: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine
• Synonyms: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine;tert-Butyl 4-(thiazol-2-yl)piperazine-1-carboxylate
• CAS NO: 474417-23-7
• Molecular Formula: C₁₂H₁₉N₃O₂S
• Molecular Weight: 269.36
• Product Categories: pharmacetical
• Mol File: 474417-23-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 380.5°C at 760 mmHg
• Flash Point: 183.9°C
• Appearance: /
• Density: 1.209g/cm³
• Vapor Pressure: 5.42E-06mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(474417-23-7)
• EPA Substance Registry System: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(474417-23-7)

Safety Data

• Hazardous Substances Data: 474417-23-7(Hazardous Substances Data)

Usage

General Description

1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is a chemical compound that belongs to the class of piperazine derivatives. It has a molecular formula C13H20N4O2S and a molecular weight of 300.39 g/mol. 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is commonly used as an intermediate in the synthesis of pharmaceutical drugs and agrochemicals. It acts as a building block in the production of various biologically active molecules due to its versatile reactivity and functional groups. Additionally, its thiazolyl and tert-butoxycarbonyl groups make it suitable for modifying the physiochemical properties of a target molecule. Overall, 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine plays a key role in medicinal chemistry and drug development.

InChI:InChI=1/C12H19N3O2S/c1-12(2,3)17-11(16)15-7-5-14(6-8-15)10-13-4-9-18-10/h4,9H,5-8H2,1-3H3

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 492431-13-7 1-(1,3-thiazol-2-yl)piperazine dihydrochloride 
• 354587-77-2 tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 1019637-75-2 tert-butyl 4-(5-methyl-1,3-thiazol-2-yl)-1-piperazinecarboxylate 
• 623588-36-3 tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate 

Relevant articles and documents

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

Copper-Catalyzed Electrophilic Amination of Heteroarenes via C-H Alumination

A highly efficient Cu-catalyzed electrophilic amination reaction of readily available heteroarenes with O-benzoyl hydroxylamines via a one-pot C-H alumination is reported. The reactions were catalyzed using 1 mol % of CuCl to afford various heteroaryl amines in good to excellent yields. The direct C-H lithiation/transalumination of heteroarenes and catalytic amination sequence can be performed in a single vessel on gram scales.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.