492454-84-9

Upstream product

• 131933-37-4 2,3-bis(benzyloxy)-terephthalic acid 
• 96-53-7 2-mercaptothiazoline 
• 19829-72-2 2,3-dihydroxyterephthalic acid 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 593247-68-8 C₂₇H₂₆N₂O₅S₂ 
• 1297532-34-3 TAM(2Li-1,2-HOPO)2(Bn)4 
• 1297532-35-4 TAM(2Li-Me-3,2-HOPO)2(Bn)4 
• 1297532-24-1 TAM(2Li-Me-3,2-HOPO)Thiaz(Bn)3 
• 1392440-33-3 2,3-bis(benzyloxy)-N₁-(4-fluorobenzyl)-N₄-methylterephthalamide 
• 882979-29-5 C₂₈H₃₂N₂O₆ 
• 1516893-29-0 C₆₁H₆₄N₆O₁₀S₄ 
• 830327-76-9 TREN-1-Me-3,2-HOPO-TAM-O₂-NH₂, benzyl protected 
• 830327-78-1 TREN-1-Me-3,2-HOPO-TAM-O₂-NH₂ 
• 953506-91-7 TREN-1-Me-3,2-HOPO-TAM-DME 
• 1610625-68-7 N,N′′-bis[2,3-dibenzyloxy-1-(2-mercaptothiazoleamido)-4-terephthalamido]-N′-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]bis(2-aminoethyl)amine 
• 1312299-46-9 C₅₄H₅₀N₄O₉S₄ 
• 1312299-48-1 (CH₃NHCOC₆H₂(OH)2CONHC₂H₄)2O 
• 1312299-47-0 C₅₀H₅₀N₄O₉ 

Relevant academic research and scientific papers

MACROCYCLES

The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

HIV INTEGRASE INHIBITORS

Provided herein, inter alia, are novel compounds for the inhibition of HIV integrase. The compounds disclosed herein are useful for methods of treating HIV infection in a subject in need thereof.

2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS

The invention provides a new class of strongly chelating multidentate ligands based on a 2-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid scaffold (hereafter 1,2-HOIQO) in combination with polyamine backbones. The extremely stable bidentate 1,2- HOIQO moiety can be synthesized by standard synthetic methodology on a large scale. An advantageous feature is the possibility to introduce a wide range of substituents on the benzene ring by standard transformations (like electrophilic aromatic substitutions). This allows, for example, for the tuning of chemical, photophysical, and solubility properties, as well as the attachment of functional moieties, relevant for sensing and imaging applications (e.g. DNA, proteins, antibodies, fluorophores, etc.). The combination of the 1,2-HOIQO chelators with polyamine backbones provides very strongly binding ligands for a variety of metals including first-row transition metals, lanthanides, actinides, etc. Metal complexes of this kind are expected to be useful in a number of applications (e.g. luminescence, MRI, actinide sequestering, metal chelation therapy, metal radioisotope labeling, etc.).

Hydroxypyridonate and hydroxypyrimidinone chelating agents

The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.