1042224-71-4Relevant academic research and scientific papers
IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding
Buckley, George M.,Ceska, Thomas A.,Fraser, Joanne L.,Gowers, Lewis,Groom, Colin R.,Higueruelo, Alicia Perez,Jenkins, Kerry,Mack, Stephen R.,Morgan, Trevor,Parry, David M.,Pitt, William R.,Rausch, Oliver,Richard, Marianna D.,Sabin, Verity
scheme or table, p. 3291 - 3295 (2009/04/05)
A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis and chemical analogue SAR.
IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines
Buckley, George M.,Fosbeary, Richard,Fraser, Joanne L.,Gowers, Lewis,Higueruelo, Alicia P.,James, Lynwen A.,Jenkins, Kerry,Mack, Stephen R.,Morgan, Trevor,Parry, David M.,Pitt, William R.,Rausch, Oliver,Richard, Marianna D.,Sabin, Verity
scheme or table, p. 3656 - 3660 (2009/04/10)
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
