4928-58-9Relevant academic research and scientific papers
Novel chromenes and benzochromenes bearing arylazo moiety: molecular docking, in-silico admet, in-vitro antimicrobial and anticancer screening
Afifi, Tarek H.,Riyadh, Sayed M.,Deawaly, Anwar A.,Naqvi, Arshi
, p. 1471 - 1487 (2019)
Novel derivatives of benzochromene 9a–e and chromene 10a–e were synthesized via multi components reaction that utilizes azo dyes, malononitrile, and arylaldehydes as starting materials. The structures of the newly synthesized compounds were elucidated by the IR, 1H-NMR, 13C-NMR and mass spectral data. The new synthesized compounds were explored for their in-silico ADMET properties. The docking investigations verified good docking outcomes in terms of score and binding affinities of the examined compounds on the desired proteins, namely the GlcN-6-P synthase and PI3Ks. The in-vitro studies, which encompassed the antibacterial activity against two types of Gm +ve and two of Gm –ve, and the antifungal activity against four fungi micro-organisms were evaluated by the well diffusion method for the synthesized compounds. Moreover, the anticancer activity was tested against three human carcinoma cell lines [human colon carcinoma (HCT-116), human breast adenocarcinoma (MCF-7), and liver carcinoma (HEPG-2)], exhibiting promising anticancer activity in comparison to Vinblastine, Colchicine and Doxorubicin as standard drugs. The data suggests that some of the new derivatives of chromene scaffold which emerged promising in the in-silico molecular docking studies displayed good in-vitro antimicrobial and anticancer activities and could be exploited as leads for further optimization.
Synthesis of new spin probes based on aminoaryl-substituted imidazoline nitroxides
Reznikov, V. A.,Berezina, T. A.,Kirilyuk, I. A.,Volodarskii, L. B.
, p. 424 - 427 (2007/10/02)
A series of new spin probes, azides and isothiocyanates, were synthesized starting from aminoaryl-substituted nitroxides which are derivatives of 3-imidazoline and 3-imidazoline-3-oxide.The new compounds were transformed to complexones, derivatives of iminodiacetic acid. - Key words: nitroxyl radical; azides; isothiocyanates; spin probes; diazonium salts.
