4931-08-2

Upstream product

• 504-29-0 2-aminopyridine 
• 100-47-0 benzonitrile 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 779-24-8 2-phenyl[1,2,4]triazolo[1,5-a]pyridine 
• 33863-66-0 4-methyl-N-(3-phenyl-4-pyridin-2-yl-4H-[1,2,4]thiadiazol-5-ylidene)-benzamide 
• 33863-69-3 phenyl-(3-phenyl-4-pyridin-2-yl-4H-[1,2,4]thiadiazol-5-ylidene)-amine 
• 99806-07-2 4-methyl-2-phenyl-1-(2-pyridyl)-cis-3a,4,9,9a-tetrahydroimidazo<4,5-b>quinoxaline 
• 1236223-42-9 6-(4-bromophenyl)-4-(morpholin-4-yl)-2-phenylpyridine-3-carbonitrile 
• 1236223-46-3 6-(4-chlorophenyl)-4-(morpholin-4-yl)-2-phenylpyridine-3-carbonitrile 
• 1236223-29-2 2',6'-diphenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-carbonitrile 
• 1236223-57-6 6-(4-chlorophenyl)-2-phenyl-4-(pyrrolidin-1-yl)pyridine-3-carbonitrile 
• 1236223-54-3 6'-(4-chlorophenyl)-2'-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-carbonitrile 
• 1236223-60-1 6'-(4-methoxyphenyl)-2'-phenyl-3,4,5,6-tetrahydro-2H-[1,4]bipyridinyl-3-carbonitrile 
• 1417815-66-7 (2E)-2-(6-(naphthalen-2-yl)-2-phenyl-3-(pyridin-2-yl)pyrimidin-4(3H)-ylidene)acetonitrile 
• 85616-12-2 3-phenyl-2H-pyrido[2,3-e][1,2,4]thiadiazine 
• 1505566-40-4 C₁₇H₁₈N₄ 
• 1459721-92-6 N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)-N′-(pyridin-2-yl)benzimidamide 

Relevant academic research and scientific papers

Transition-Metal-Free Synthesis of 1,2-diphenyl-1H-benzo[d] Imidazole Derivatives from N-phenylbenzimidamides and Cyclohexanones

A transition-metal-free strategy for the formation of 1,2-diphenyl-1H-benzo[d] imidazoles from N-phenylbenzimidamides and cyclohexanones is introduced. This is the first report on the direct synthesis of 1,2-diphenyl-1H-benzo[d] imidazoles from cyclohexanones and N-phenylbenzimidamides via iodine- promoted oxidative cyclization. Non-aromatic cyclohexanones were smoothly dehydrogenated, and acted as an aryl source using oxygen as a green oxidant. The catalytic use of iodine makes this method quite simple, more economical and convenient. Under optimized conditions, various substituted 1,2-diphenyl-1H-benzo[d] imidazoles were smoothly reacted, and the desired substituted imidazoles were generated with moderate to excellent yields. (Figure presented.).

Base-Mediated Amination of Alcohols Using Amidines

Novel and efficient base-mediated N-alkylation and amidation of amidines with alcohols have been developed, which can be carried out in one-pot reaction conditions, which allows for the synthesis of a wide range of N-alkyl amines and free amides in good to excellent yields with high atom economy. In contrast to borrowing hydrogen/hydrogen autotransfer or oxidative-type N-alkylation reactions, in which alcohols are activated by transition-metal-catalyzed or oxidative aerobic dehydrogenation, the use of amidines provides an effective surrogate of amines. This circumvents the inherent necessity in N-alkylation of an oxidant or a catalyst to be stabilized by ligands.

PhI(OAc) 2 -Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5- a ]pyridines via Oxidative N-S and N-N Bond Formation

An effective and expeditious approach for the construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5- a ]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc) su

The dearomative annulation between N -2-pyridylamidine and CO2 toward pyrido[1,2-a]-1,3,5-triazin-4-ones

A base-promoted dearomative annulation between N-2-pyridylamidine and an atmospheric pressure of CO2 was developed, affording a series of pyrido[1,2-a]-1,3,5-triazin-4-ones in moderate to excellent yields. CO2 served as a carbonyl so

Vanadium-Catalyzed Oxidative C(CO)-C(CO) Bond Cleavage for C-N Bond Formation: One-Pot Domino Transformation of 1,2-Diketones and Amidines into Imides and Amides

A novel vanadium-catalyzed one-pot domino reaction of 1,2-diketones with amidines has been identified that enables their transformation into imides and amides. The reaction proceeds by dual acylation of amidines via oxidative C(CO)-C(CO) bond cleavage of 1,2-diketones to afford N,N′-diaroyl-N-arylbenzamidine intermediates. In the reaction, these intermediates are easily hydrolyzed into imides and amides through vanadium catalysis. This method provides a practical, simple, and mild synthetic approach to access a variety of imides as well as amides in high yields. Moreover, one-step construction of imide and amide bonds with a long-chain alkyl group is an attractive feature of this protocol.

I2/KI-Mediated Oxidative N-N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N -Aryl Amidines

An I2/KI-mediated oxidative N-N bond formation reaction is described. This new and environmentally benign approach allows for the convenient synthesis of a variety of 1,2,4-triazolo[1,5-a]pyridines and other 1,5-fused 1,2,4-triazoles from readi

PhI(OCOCF3)2-mediated intramolecular oxidative N-N bond formation: Metal-free synthesis of 1,2,4-triazolo[1,5-a]pyridines

The biologically important 1,2,4-triazolo[1,5-a]pyridines were readily synthesized from N-(pyridin-2-yl)benzimidamides via phenyliodine bis(trifluoroacetate)-mediated intramolecular annulation. This novel strategy allows for the convenient construction of a 1,2,4-triazolo[1,5-a]pyridine skeleton through direct metal-free oxidative N-N bond formation, featuring a short reaction time and high reaction yields.

A convenient regioselective synthesis of (2E)-2-[2,3,6-triarylpyrimidin- 4(3H)-ylidene]acetonitriles through ring transformation reactions

We report a greener, economical, highly convenient and regioselective synthesis of (2E)-2-[2,3,6-arylpyrimidin-4(3H)-ylidene)acetonitriles derivatives 3. This is achieved by a strategy involving ring transformation reaction of 4-(methylthio)-2-oxo-6-aryl-

Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization

A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process should consist of sequential N-C and N-N bond-forming copper-catalyzed oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated to achieve chemical diversity.

Adsorptive stripping voltammetric determination of nickel(II) using N-2-pyridyl-benzamidine as a complexing reagent

An adsorptive stripping voltammetric method for the trace measurement of nickel(II) based on the use of N-2-pyridyl- benzamidine as the complexing agent at hanging mercury drop electrode in 0.8 M NH4Cl/NH3 buffer of pH 9.6 is describ