4936-83-8Relevant academic research and scientific papers
A mechanistic approach for in-vitro anticancer activity via nucleic acid fragmentation by copper(II) complex anchored on MCM-41
Biswas, Subhendu,Das, Debasis,Dasgupta, Sanchari,Karim, Suhana,Parveen, Rumana
, (2022/01/11)
Three new mononuclear copper Schiff base complexes, namely, ([Cu(L1)Cl].CH3CN (HmC_1), [Cu(L2)Cl].CH3CN (HmC_2) and [Cu(L3)Cl].CH3CN (HmC_3) derived from ONO donor tridentate ligands HL1, HL2 and HL3, respectively, have been synthesized to check their efficacy as target-specific next-generation anticancer therapeutics. All the HmCs have been characterized by using various physicochemical techniques (i.e., single-crystal X-ray analysis, Fourier transform infrared [FT-IR] spectroscopy and elemental analysis). Among the synthesized Schiff base complexes, HmC_3 was turned out to be most effective in killing cancer cell carried out on cultured human breast cancer cell line (MDA-MB-231) and human lung carcinoma cell line (A549). Finally, in order to improve the cellular permeability, particle size of HmC_3 was scaling down to nano-regime by immobilizing it onto a suitable matrix MCM-41@APTES (MCM-41 = Mobil Composition of Matter No. 41 and APTES = 3-aminopropyltriethoxysilane) to generate MCM-41@APTES@HmC_3 (MCM-41@APTES@HmC_3 = HtC_3). Field-emission scanning electron microscope (FESEM) and dynamic light scattering (DLS) study revealed the particle size of the synthesized HtC_3 nano-composite was within nano-regime and therefore could be further effective for biomedical applications. Furthermore, HtC_3 displayed better cancer cell killing property. To get insight into the mechanism of action of HtC_3, Annexin V-FITC/PI analysis and TUNEL assay revealed that DNA damage phenomenon is accompanied with changes in cellular morphology leading to cell apoptosis. Cell migration assay on MDA-MB-231 cell with HtC_3 exposed the effectiveness of HtC_3 in arresting cancer cell migration. Therefore, all the in-vitro studies demonstrated that the immobilization of the copper Schiff base complex onto a suitable matrix increased its efficiency and becomes a promising anticancer nano-therapeutic agent.
A Schiff base zinc compound, preparation method thereof and method for producing polylactic acid
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Paragraph 0101; 0102; 0104, (2017/10/27)
The invention provides a schiff base zinc compound which is in a structure as shown in Formula 1, wherein R1 and R2 are independently selected from -H, alkyl, halogen and -NO2; R3, R4 and R5 are independently selected from -H and -CH3; R' is alkoxyl or -O
A Schiff base aluminum compound, preparation method thereof and method for producing polylactic acid
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Paragraph 0111; 0112; 0113; 0114, (2017/08/25)
The invention provides a Schiff base aluminum compound and a preparation method thereof, and a polylactic acid preparation method. The Schiff base aluminum compound provided by the invention has a structure shown in Formula (I) or Formula (II), wherein R1
Racemization of secondary alcohols catalyzed by ruthenium: Application to chemoenzymatic dynamic resolution
Merabet-Khelassi, Mounia,Vriamont, Nicolas,Aribi-Zouioueche, Louisa,Riant, Olivier
experimental part, p. 1790 - 1796 (2012/01/03)
In this paper, we have shown that the [RuCl2(p-cymene)] 2 complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2(p-cymene)]2/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out dynamic kinetic resolution experiments on rac-phenylethanol. This led us to identify the best conditions for effective DKR, which was then applied to various secondary benzylic and aliphatic alcohols. It was thus possible to obtain (R)-1-cyclohexylethyl acetate from rac-1-cyclohexylethanol in quantitative conversion and with high enantioselectivity (98%).
