4939-03-1Relevant academic research and scientific papers
Identification of small-molecule inhibitors of the Aβ-ABAD interaction
Xie, Yuli,Deng, Shixian,Chen, Zhenzhang,Yan, Shidu,Landry, Donald W.
, p. 4657 - 4660 (2007/10/03)
The interaction of amyloid beta peptide (Aβ) and Aβ-binding alcohol dehydrogenase (ABAD) was recently implicated in the pathogenesis of Alzheimer's disease (AD). Using an ELISA-based screening assay, we identified frentizole, an FDA-approved immunosuppressive drug, as a novel inhibitor of the Aβ-ABAD interaction. Analysis of the frentizole structure-activity relationship led to identification of a novel benzothiazole urea with a 30-fold improvement in potency.
