494189-91-2

Upstream product

• 150356-87-9 7-(4-chlorophenyl)-2,3-dihydro-5-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one 
• 74-88-4 methyl iodide 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 

Downstream Products

• 494190-05-5 2-hydrazino-5-phenyl-7-(4-chlorophenyl)-3H,4H-pyrido[2,3-d]pyrimidin-4(4H)-one 

Relevant academic research and scientific papers

Synthesis of some new thiazolo[3,2-a]pyrido[2,3-d]pyrimidinones and isoxazolo[5′,4′:4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone

6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone 1 reacts in boiling DMF with a cyclic α,β-unsaturated ketones 2 affording the pyrido [2,3-d]pyrimidinone 6a,b, the latter compound condensed with aldehyde in presence of chloroacetic acid to yield thiazolo[3,2-a] pyrido [2,3-d]-pyrimidinones (7, 8) respectively. The alkylation of pyridopyrimidinone it gave the 2-alkylthio derivatives 10a-e, compound 10b cyclized to thiazolopyridopyrimidinone derivative 13. Also, the condensation of compounds 7a,b with hydoxylamine gave the corresponding isoxazolo[5′,4′:4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone.