494190-05-5

Upstream product

• 150356-87-9 7-(4-chlorophenyl)-2,3-dihydro-5-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 494189-91-2 7-(4-chlorophenyl)-2-methylthio-5-phenyl-3H,4H-pyrido[2,3-d]pyrimidin-4-one 

Downstream Products

• 1111872-02-6 3-mercapto-6-phenyl-8-(4-chlorophenyl)-1H,3H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(5H)-one 
• 1111872-01-5 6-phenyl-8-(4-chlorophenyl)-1H,3H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(5H)-one 
• 1111872-05-9 2-xylosylhydrazino-5-phenyl-7-(4-chlorophenyl)-3H,6H-pyrido[2,3-d]pyrimidin-4-one 
• 1111872-06-0 2-glucosylhydrazino-5-phenyl-7-(4-chlorophenyl)-3H,6H-pyrido[2,3-d]pyrimidin-4-one 
• 1111871-97-6 2-(phenylmethylenehydrazone)-7-(4-chlorophenyl)-3H,4H-pyrido[2,3-d]pyrimidin-4-one 
• 1111871-98-7 2-(4-methoxyphenylmethylenehydrazone)-5-phenyl-7-(4-chlorophenyl)-3H,4H-pyrido[2,3-d]pyrimidin-4-one 
• 1111872-03-7 8-(4-chlorophenyl)-1H,5H-tetrazolo[1,5-a]pyrido[2,3-d]pyrimidin-5-one 

Relevant academic research and scientific papers

Synthesis and reactions of some novel triazolo-, azolo-, tetrazolo-pyridopyrimidine and their nucleoside derivatives

Pyridopyrimidine reacted with aromatic aldehydes afforded the arylhydrazone 2a,b which could be cyclized into the pyrido[2,3-d][1,2,4]triazolo[4,3-a] pyrimidine 3a,b, with formic acid, and carbon disulphide to give pyrido[2,3-d][1,2,4]traizolo[4,3-a]pyrimidine 4, 5. Reaction of 1 with nitrous acid afforded tetrazolo[1,5-a]pyrido[2,3-d]pyrimidine 6, which was reduced by zinc dust to give 2-amino-pyrido-[2,3-d]pyrimidine 7. Finally the reaction of 2-hydrazino 1 with D-xylose or D-glucose afforded the acyclic N-nucleoside 8, 11 which were converted into tetra/penta O-acetate acyclic C-nucleoside 9, 12 in acetic anhydride/pyridine. De-acetylation of compounds 9, 12 afforded C-nucleosides 10, 13.

Synthesis of some new thiazolo[3,2-a]pyrido[2,3-d]pyrimidinones and isoxazolo[5′,4′:4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone

6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone 1 reacts in boiling DMF with a cyclic α,β-unsaturated ketones 2 affording the pyrido [2,3-d]pyrimidinone 6a,b, the latter compound condensed with aldehyde in presence of chloroacetic acid to yield thiazolo[3,2-a] pyrido [2,3-d]-pyrimidinones (7, 8) respectively. The alkylation of pyridopyrimidinone it gave the 2-alkylthio derivatives 10a-e, compound 10b cyclized to thiazolopyridopyrimidinone derivative 13. Also, the condensation of compounds 7a,b with hydoxylamine gave the corresponding isoxazolo[5′,4′:4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone.