494224-08-7Relevant articles and documents
Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists
Kambe, Tohru,Maruyama, Toru,Nakai, Yoshihiko,Oida, Hiroji,Maruyama, Takayuki,Abe, Nobutaka,Nishiura, Akio,Nakai, Hisao,Toda, Masaaki
, p. 3502 - 3522 (2012/07/30)
To identify topically effective EP4 agonists and EP2/EP4 dual agonists with excellent subtype selectivity, further optimization of the 16-phenyl ω-chain moiety of the γ-lactam 5-thia prostaglandin E analog and the 2-mercaptothiazole-4-carboxylic acid anal