4943-88-8

Upstream product

• 66-72-8 pyridoxal 
• 62-53-3 aniline 
• 65-22-5 pyridoxal hydrochloride 
• 3768-55-6 N-trimethylsilylaniline 

Downstream Products

• 132120-28-6 (4-Anilinomethyl-5-hydroxy-6-methyl-[3]pyridyl)-methanol 
• 132120-34-4 (8-Methyl-3-phenyl-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol 

Relevant academic research and scientific papers

Pyridoxal derivatized copper(II) complexes: Evaluation of antioxidant, catecholase, and DNA cleavage activity

This manuscript describes the synthesis, characterization and structural analysis of copper(II) complexes with pyridoxal-type bidentate ligands, obtained from the condensation between pyridoxal and ortho-halogenated substituted anilines (C1–C5). The complexes C1, C2 and C5 were measured by X-ray single crystal analysis which showed classic and trifurcated hydrogen bonds and interaction as a sigma-hole between the oxygen atoms of the iodine ligand derivative in the complex C5. All compounds were tested as mimetics of superoxide dismutase (SOD), through NBT photoreduction method in aqueous solution of pH 7.8, but the complex C5 showed an expressive IC50 of 0.4 μM. In addition, catecholase-like activity of C1–C5 in the presence of the substrate 3,5-di-tert-butylcatechol and cleavage of plasmid DNA were also evaluated. Again, the best results were associated with the complex C5 containing iodine in the ortho position.

Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy

A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.