494748-00-4

Upstream product

• 494747-94-3 6-benzyloxy-3-[1-methyl-2,5-dioxo-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,5-dihydro-1H-pyrrol-3-yl]indole-1-carboxylic acid tert-butyl ester 
• 174402-44-9 tert-butyl 6-(benzyloxy)-3-(4-bromo-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole-1-carboxylate 
• 494747-97-6 6-methyl-10-benzyloxy-13H-pyrrolo[2,3-a]pyrrolo[3,4-c]pyrido[3',2':4,5]carbazole-5,7-dione-12-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 7-azaindolocarbazoles

In the course of a program aimed at designing antitumor agents containing an indolocarbazole framework, an efficient synthetic scheme based on the use of 3,4-dibromo-N-methylmaleimide and 7-azaindole has been developed to elaborate a series of mono- and di-aza derivatives of arcyriaflavin. The procedure was further exploited to introduce a hydroxyl group at different positions on the indole moiety of the non-symmetrical compounds. The DNA binding capacity and cytotoxic potential of these 7-azaindolocarbazole derivatives was evaluated.