494762-68-4Relevant academic research and scientific papers
Iridium-Catalyzed Aryl C-H Sulfonamidation and Amide Formation Using a Bifunctional Nitrogen Source
Yu, Meng,Zhang, Tao,Jalani, Hitesh B.,Dong, Xunqing,Lu, Hongjian,Li, Guigen
supporting information, p. 4828 - 4832 (2018/08/24)
A new strategy for the sequential formation of aryl and amidyl C-N bonds is reported. Using trichloroethoxysulfonyl azide as a bifunctional nitrogen source, Ir-catalyzed aryl C-H sulfonamidation and subsequent desulfonative amide formation proceed effectively without any need of oxidants or coupling reagents. This protocol is suitable for readily available benzamides and stable carboxylates including primary, secondary, and tertiary alkyl, alkenyl, and phenyl carboxylates, thereby providing a direct and efficient method for the synthesis of biologically and chemically useful N-arylamides.
Mechanochemical Rhodium(III)-Catalyzed C-H Bond Amidation of Arenes with Dioxazolones under Solventless Conditions in a Ball Mill
Hermann, Gary N.,Bolm, Carsten
, p. 4592 - 4596 (2017/07/24)
A procedure for the direct mechanochemical rhodium(III)-catalyzed C-H bond amidation of arenes with 1,4,2-dioxazol-5-ones as the nitrogen source has been developed. The transformation proceeds under solventless conditions and does not require additional h
Expedient Synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates
Hesp, Kevin D.,Bergman, Robert G.,Ellman, Jonathan A.
supporting information; experimental part, p. 11430 - 11433 (2011/10/02)
A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C-H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.
