494803-88-2

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 494803-86-0 2-amino-1-(1-benzenesulfonyl-1H-indol-3-yl)-ethanol 

Downstream Products

• 494803-93-9 (S)-2-Acetylamino-4-methyl-pentanoic acid {(S)-1-[(E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-vinylcarbamoyl]-2-phenyl-ethyl}-methyl-amide 
• 494803-92-8 N-[2-(1-benzenesulfonyl-1H-indol-3-yl)-vinyl]-2-methylamino-3-phenyl-propionamide 
• 494803-90-6 {1-[2-(1-benzenesulfonyl-1H-indol-3-yl)-vinylcarbamoyl]-2-phenyl-ethyl}-methyl-carbamic acid tert-butyl ester 
• 494803-91-7 N-[2-(1-benzenesulfonyl-1H-indol-3-yl)-2-hydroxy-ethyl]-2-methylamino-3-phenyl-propionamide 

Relevant academic research and scientific papers

A short synthesis of aspergillamide B. The marine natural product from Aspergillus sp.

A short route to the marine natural product aspergillamide B has been developed. The key step is the stereoselective formation of the trans indole-enamide pharmacophore by indole-assisted dehydration from the functionalized aminoalcohol intermediate. HPLC and 1H NMR analyses show that aspergillamide B is more stable in the cis rotamer form.