494833-86-2

Upstream product

• 109-87-5 Dimethoxymethane 
• 494833-87-3 N-(3-bromophenethyl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 58971-11-2 2-(3-bromophenyl)ethanamine 
• 1036378-89-8 2-(4-bromobenzylamino)acetaldehyde dimethyl aceta 
• 1122-91-4 4-bromo-benzaldehyde 
• 1036378-91-2 N-(4-bromo-benzyl)-N-(2,2-dimethoxy-ethyl)-4-methyl-benzenesulfonamide 

Downstream Products

• 1350377-10-4 6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline 
• 1350468-20-0 C₂₇H₄₁N₃O₂ 
• 1350411-07-2 (4-methoxy-phenyl)-[6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone 
• 1350411-19-6 6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (3-methoxy-phenyl)-amide 
• 1350411-17-4 2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction

A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines (THIQs) is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate 4-hydroxy-THIQ. This method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.

Regioselective assembly of 3,4-dihydroisoquinoline derivatives

A facile two-step sequence (9→10→1) of regioselective assembly of 3,4-dihydroisoquinoline derivatives 1 is reported. The halogen derivatives provide opportunity for Suzuki, Buchwald, and related coupling reactions useful for expanding the scaffold and lea

SUBSTITUTED N-HETEROARYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

The present invention discloses and claims a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of Formula (I). Wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this in

SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

The present invention discloses and claims a series of substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives of formula (I). Wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of t