494836-63-4

Upstream product

• 147124-34-3 dimethyl 2-(5-fluoro-2-nitrophenyl)malonate 
• 446-35-5 2,4-Difluoronitrobenzene 
• 50-00-0 formaldehyd 

Downstream Products

• 1291103-92-8 (4S,5R)-2,2-diethyl 4-methyl 4-(5-fluoro-2-nitrophenyl)-5-phenylpyrrolidine-2,2,4-tricarboxylate 
• 391277-53-5 methyl 2-(5-methoxy-2-nitrophenyl)acrylate 
• 1291104-20-5 (4S,5R)-2,2-diethyl 4-methyl 4-(5-methoxy-2-nitrophenyl)-5-phenylpyrrolidine-2,2,4-tricarboxylate 

Relevant academic research and scientific papers

Asymmetic organocatalytic 1,3-dipolar cycloaddition of azomethine ylide to methyl 2-(2-nitrophenyl)acrylate for the synthesis of diastereoisomers of spirotryprostatin A

Chemical equations presented. The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted aci

A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: A short synthesis of (±)-coerulescine and (±)-horsfiline

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their phenyl ring using common and less expensive reagents is described. The usefulness of this methodology is substantiated by the efficient total syntheses of (±)-coerulescine and (±)-horsfiline from the 2-arylpropenoic acid esters obtained.