494841-73-5Relevant articles and documents
Asymmetric synthesis of a selective endothelin a receptor antagonist
Kato, Yoshiaki,Niiyama, Kenji,Jona, Hideki,Okada, Shigemitsu,Akao, Atsushi,Hiraga, Shouichi,Tsuchiya, Yoshimi,Tomimoto, Koji,Mase, Toshiaki
, p. 1066 - 1072 (2007/10/03)
An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. Asymmetric conjugate addition of aryllithium derived from 18 to the chiral oxazoline 17 followed by hydrolysis afforded 15 in 96% ee via purification as (S)-(-)-1-phe