495388-45-9

Upstream product

• 2043-53-0 2-(n-perfluorooctyl)ethyl iodide 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 21652-58-4 1H,1H,2H-perfluorodecene 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 495388-44-8 4-((E)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluoro-dec-1-enyl)-benzoic acid methyl ester 

Downstream Products

• 865758-36-7 4,4'dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl chloride 
• 865758-39-0 5'-O-[4,4'-dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl]thymidine 
• 865758-41-4 N⁴-benzoyl-5'-O-[4,4'-dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl]-2'-deoxycytidine 
• 865758-40-3 N⁶-benzoyl-5'-O-[4,4'-dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl]-2'-deoxyadenosine 
• 865758-42-5 5'-O-[4,4'-dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl]-N²-isobutyryl-2'-deoxyguanosine 
• 495388-41-5 4-(1H,1H,2H,2H-perfluorodecyl)benzyl chloroformate 
• 1585235-84-2 15-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14-pentaoxapentadecane 
• 1585235-85-3 C₂₅H₂₇F₁₇O₅ 
• 1585235-86-4 27-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane 
• 1585235-87-5 ((3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol 
• 1585235-88-6 9-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxanonatriacontane 

Relevant academic research and scientific papers

Fluorous synthesis of mono-dispersed poly(ethylene glycols)

Mono-dispersed poly(ethylene glycols) (PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based solid-phase extractions were successfully employed to simplify the purifications. This synthesis provided an easy access to valuable mono-dispersed PEGs and related molecules for biomedical application on multi-gram scales.

Use of benzyloxycarbonyl (Z)-based fluorophilic tagging reagents in the purification of synthetic peptides

Three novel fluorous reagents (i.e. 1-3), derived from benzyl chloroformate (Z-Cl), have been synthesized and used for the tagging of peptides prepared following a Fmoc-based solid-phase approach. It is shown that the implementation of a benzyloxycarbonyl (Z)-based fluorophilic tag facilitates purification of peptides using fluorous reverse phase chromatography.