1585235-85-3Relevant articles and documents
Fluorous synthesis of mono-dispersed poly(ethylene glycols)
Li, Yu,Guo, Qi,Li, Xuefei,Zhang, Hua,Yu, Fanghua,Yu, Weijiang,Xia, Guiquan,Fu, Mingyang,Yang, Zhigang,Jiang, Zhong-Xing
, p. 2110 - 2113 (2014/04/03)
Mono-dispersed poly(ethylene glycols) (PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based solid-phase extractions were successfully employed to simplify the purifications. This synthesis provided an easy access to valuable mono-dispersed PEGs and related molecules for biomedical application on multi-gram scales.