495414-06-7

Basic information

• Product Name: 4-Bromo-2-(bromomethyl)-1-iodobenzene
• Synonyms: 4-Bromo-2-(bromomethyl)-1-iodobenzene;5-Bromo-2-iodobenzyl bromide 95+%;5-bromo-2-iodobenzyl bromide
• CAS NO: 495414-06-7
• Molecular Formula: C₇H₅Br₂I
• Molecular Weight: 376
• Mol File: 495414-06-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Bromo-2-(bromomethyl)-1-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-(bromomethyl)-1-iodobenzene(495414-06-7)
• EPA Substance Registry System: 4-Bromo-2-(bromomethyl)-1-iodobenzene(495414-06-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 495414-06-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(bromomethyl)-1-iodobenzene is a chemical compound known for its three halogen atoms attached to the phenyl ring — an iodine and two bromine atoms. Its molecular formula is C7H5Br2I, depicting seven carbon, five hydrogen, two bromine, and one iodine atoms in each molecule. It's commonly used as a building block, reagent, or intermediate in a variety of chemical reactions, often in the area of organic synthesis or pharmaceutical development. It's typically a solid substance at room temperature with important storage safety precautions due to its reactive halogen nature. Details about its exact physical and chemical properties, such as melting point, boiling point, density, and solubility, are determined mostly by empirical information and may vary slightly based on the conditions presented.

Upstream product

• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 199786-58-8 (5-bromo-2-iodo-phenyl)-methanol 

Downstream Products

• 1178576-94-7 2-benzenesulfonylmethyl-4-bromo-1-iodo-benzene 
• 1278522-46-5 (Z)-1,2-bis(5-bromo-2-iodophenyl)ethene 
• 1279129-78-0 (5-bromo-2-iodobenzyl)triphenylphosphonium bromide 
• 1279129-98-4 2,8-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-99-5 3,7-bis(trimethylsilylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-81-5 2,8-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-83-7 3,7-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-77-9 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-80-4 2,8-di(thiophen-2-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-89-3 2,8-di([2,2'-bithiophen]-5-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-90-6 2,8-bis(phenylethynyl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-92-8 3,7-di([2,2'-bithiophen]-5-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-95-1 2,8-bis(diphenylamino)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin 
• 1279129-96-2 5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin-2,8-dicarboxylic acid 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

CuSO4-Catalyzed dual annulation to synthesize O, S or N-containing tetracyclic heteroacenes

In this work, CuSO4 is utilized as a practical redox catalyst for tandem dual annulation in the synthesis of indole-fused tetracyclic heteroacenes, which are important skeletons in both medicinal chemistry and materials chemistry. The preparation of such skeletons in a convenient and efficient manner is in high demand. This method realizes the modular synthesis of benzofuro-, benzothieno-, and indoloindoles from abundant feedstocks such as 2-halobenzyl halides and nitrile derivatives in up to 99% yields, providing a rapid access to diverse indole-fused heteroacenes with biological or optoelectronic properties.

Phenanthroline- tBuOK Promoted Intramolecular C-H Arylation of Indoles with ArI under Transition-Metal-Free Conditions

The first example of phenanthroline-tBuOK promoted intramolecular radical C-H arylation of N-(2-iodobenzyl)indoles without involvement of transition metals has been developed. A variety of substituted 6H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient intramolecular cyclization using 1,10-phenanthroline in the presence of potassium tert-butoxide and chlorobenzene. This strategy provides a fast and versatile access to isoindolo[2,1-a]indole derivatives for the synthesis of pharmaceuticals and organic electroluminescent (EL) materials.