495414-58-9Relevant articles and documents
Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands
Bleicher, Konrad H.,Wuethrich, Yves,De Boni, Maxime,Kolczewski, Sabine,Hoffmann, Torsten,Sleight, Andrew J.
, p. 2519 - 2522 (2002)
The combination of the 3,5-bis(trifluoromethyl)phenyl group with a spirohydantoin motive as a central scaffold was the basis for the design of a combinatorial library targeted towards the neurokinin-1 receptor. A solution- and solid-phase procedure is described and binding affinities of representative compounds presented.
