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49557-75-7

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Product FOB Price Min.Order Supply Ability Supplier
Copper Peptide/Growth-modulating peptide Glycyl-L-Histidyl-L-Lysine
Cas No: 49557-75-7
No Data 1 Kilogram 1 Metric Ton/Month Kono Chem Co.,Ltd Contact Supplier
skin renewal anti Wrinkle agents Copper Tripeptide-1
Cas No: 49557-75-7
USD $ 200.0-250.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Guangzhou Trojan Pharmatech Ltd Contact Supplier
High Quality Cosmetic Grade Copper peptide GHK Cu
Cas No: 49557-75-7
No Data 1 Kilogram Metric Ton/Day Xi'an Harmonious Natural Bio-Technology Co., Ltd. Contact Supplier
Copper Peptide 49557-75-7
Cas No: 49557-75-7
No Data 1 Gram 3 Metric Ton/Month Qingdao Beluga Import and Export Co., LTD Contact Supplier
Lower price Copper peptide GHK-Cu
Cas No: 49557-75-7
USD $ 10.0-30.0 / Gram 10 Gram 50 Kilogram/Year Sinoway Industrial Co., Ltd. Contact Supplier
Glycyl-L-Histidyl-L-Lysine
Cas No: 49557-75-7
USD $ 12.0-12.0 / Gram 10 Gram 500 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Copper Peptide/Growth-modulating peptide GHK-Cu
Cas No: 49557-75-7
No Data 10 Gram 1 Metric Ton/Month Sichuan Jiayinglai Technology Co,Ltd (Enlai Biotech) Contact Supplier
copper tripeptide-1
Cas No: 49557-75-7
No Data 1 Milligram Metric Ton/Day Zhejiang Peptites Biotech Co.,Ltd Contact Supplier
Glycyl-l-histidyl-l-lysine GHK Cu manufacturer high quality
Cas No: 49557-75-7
No Data 1 Gram 100 Kilogram/Week Shanghai AngewChem Co., Ltd. Contact Supplier
High quality copper tripeptide-1 supplier in China
Cas No: 49557-75-7
No Data 1 Kilogram 2000 Metric Ton/Year Simagchem Corporation Contact Supplier

49557-75-7 Usage

Definition

ChEBI: A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.

Pharmaceutical Applications

Glycyl-l-histidyl-l-lysine (GHK) is a tripeptide known for its high binding affinity to Cu2+ and its complex role in wound healing. The GHK–Cu(II) complex was isolated from human plasma in the 1970s and it was shown to be an activator for wound healing. GHK–Cu(II) has two main functions: as an anti-inflammatory agent to protect the tissue from oxidative damage after the injury, and as an activator for wound healing itself as it activates the tissue remodelling. The structure of GHK is very similar to that of common drugs used to treat ulcers. After the initial stages of wound healing are activated, such as blood coagulation and neutrophil invasion, a second stage of wound healing begins, which includes the population of GHK at the wound, which has a high affinity to Cu2+. Mast cells, which are located in the skin, secrete GHK, which accumulates Cu2+ and forms the copper complex GHK–Cu(II) and therefore increases the metal–tripeptide concentration at the wound. First, GHK–Cu(II) has an anti-inflammatory effect by protecting the tissue from oxidative damage and by suppressing local inflammatory signals (i.e. cytokine interleukin-1 (IL-1)). Second, GHK–Cu(II) is released into the blood stream and encourages the production of wound macrophages that support the wound repair by removing the damaged tissue and secreting a family of several growth factor proteins. GHK–Cu(II) also hinders fibroblast production of TGF-β-1 and therefore suppresses the scar development. The GHK–Cu(II) complex also stimulates the growth of blood vessels, neurons and elastin, and, in general, supports most processes of wound healing.

Uses

anti-wrikle
InChI:InChI=1/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)

49557-75-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Gly-His-Lys

1.2 Other means of identification

Product number -
Other names Ahk-cu

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:49557-75-7 SDS

49557-75-7Synthetic route

N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Lys(tert-butoxycarbonyl)
71989-26-9

Fmoc-Lys(tert-butoxycarbonyl)

Fmoc-His(Trt)-OH
109425-51-6

Fmoc-His(Trt)-OH

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

Conditions
ConditionsYield
Multistep reaction;40%
malondialdehyde
64516-48-9

malondialdehyde

acetaldehyde
75-07-0

acetaldehyde

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

(S)-6-Amino-2-[(S)-2-[2-(3,5-diformyl-4-methyl-4H-pyridin-1-yl)-acetylamino]-3-(1H-imidazol-4-yl)-propionylamino]-hexanoic acid

(S)-6-Amino-2-[(S)-2-[2-(3,5-diformyl-4-methyl-4H-pyridin-1-yl)-acetylamino]-3-(1H-imidazol-4-yl)-propionylamino]-hexanoic acid

Conditions
ConditionsYield
In water at pH 4.2;
biotin pentafluorophenyl ester
120550-35-8

biotin pentafluorophenyl ester

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

C24H38N8O6S

C24H38N8O6S

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 5h;
PEG succinimidyl propionate derivative

PEG succinimidyl propionate derivative

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

PEG-glycyl-L-histidyl-L-lysine

PEG-glycyl-L-histidyl-L-lysine

Conditions
ConditionsYield
at 20℃;
at 20℃;
potassium tetrachloropalladate(II)

potassium tetrachloropalladate(II)

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

[(NH2(CH2CO)NCH(CONHCH(COO)CH2CH2CH2CH2NH3)CH2(CCHNHCHN))PdCl]

[(NH2(CH2CO)NCH(CONHCH(COO)CH2CH2CH2CH2NH3)CH2(CCHNHCHN))PdCl]

Conditions
ConditionsYield
In water acidic soln.;; monitored by (1)H/(13)C-NMR spectroscopy;;
In water-d2 acidic soln.;; monitored by (1)H/(13)C-NMR spectroscopy;;
copper diacetate
142-71-2

copper diacetate

glycyl-L-histidyl-L-lysine
49557-75-7

glycyl-L-histidyl-L-lysine

copper tripeptide-1

copper tripeptide-1

Conditions
ConditionsYield
With sodium methylate In methanol; water at 20℃; for 2h;

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