49574-16-5Relevant articles and documents
Copper(i) iodide-catalyzed synthesis of N,N′-disubstituted guanidines from n-substituted cyanamides
Zeng, Cian-Jhe,Chen, Chia-Jung,Chang, Chih-Wei,Chen, Hui-Ting,Chien, Tun-Cheng
, p. 1134 - 1137 (2014)
A facile and effective synthesis of N-alkyl-N′-arylguanidines was accomplished by the reaction of N-arylcyanamides with various primary and secondary alkylamines, under the catalysis of copper(i) iodide and Xantphos in DMF. This methodology provides a direct access to versatile N,N′- disubstituted guanidine derivatives from N-arylcyanamides that can be readily prepared from the corresponding nitriles via Tiemann rearrangement. CSIRO 2014.
