49582-20-9Relevant academic research and scientific papers
Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking
Lawrence, Harshani R.,Li, Zhenyu,Richard Yip,Sung, Shen-Shu,Lawrence, Nicholas J.,McLaughlin, Mark L.,McManus, Gregory J.,Zaworotko, Michael J.,Sebti, Said M.,Chen, Jiandong,Guida, Wayne C.
, p. 3756 - 3759 (2009)
NSC 333003 has been identified from the NCI Diversity Set as an inhibitor of the MDM2-p53 protein-protein interaction by in silico docking (virtual screening). Its potency and chemical characteristics render it well suited for lead optimization studies th
Dioxidovanadium(V) complexes containing thiazol-hydrazone NNN-donor ligands and their catalytic activity in the oxidation of olefins
Ghorbanloo, Massomeh,Jafari, Solmaz,Bikas, Rahman,Krawczyk, Marta S.,Lis, Tadeusz
, p. 15 - 24 (2016/10/26)
The reaction between tridentate NNN donor ligands, (E)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)benzo[d]thiazole (HL1) and (E)-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)benzo[d]thiazole (HL2), with VO(acac)2in ethanol gave [VO2(L1)] (1) and [VO2(L2)] (2) complexes. Complex [VO2(L2)]·0.2(H2O) (3) was produced from the reaction of HL2and V2O5in ethanol. Molecular structures of complexes were determined by single-crystal X-ray diffraction. All of the investigated compounds were further characterized by elemental analysis, FT-IR, UV–vis and NMR spectroscopy. The dioxidovanadium(V) species were used as catalysts for olefin oxidation in the presence of hydrogen peroxide (H2O2) as an oxidant. Under similar experimental conditions with equal vanadium loading, the presence of the [VO2(L1)] (1) resulted in higher conversion than in the case of using [VO2(L2)] (2) and [VO2(L2)]·0.2(H2O) (3) as catalytic agents.
