49593-01-3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 49593-00-2 3r,6t-dimercapto-1,4-dimethyl-piperazine-2,5-dione 
• 19552-98-8 3r,6c-dimercapto-1,4-dimethyl-piperazine-2,5-dione 
• 19552-98-8 3,6-dimercapto-1,4-dimethylpiperazine-2,5-dione 
• 61760-32-5 (3R,6R)-3,6-Bis-methoxymethylsulfanyl-1,4-dimethyl-piperazine-2,5-dione 

Downstream Products

• 79247-54-4 (1R,5R)-1-Benzyl-3-(4-methoxy-phenyl)-6,8-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 57119-34-3 (1R,5R)-1-Ethyl-3-(4-methoxy-phenyl)-6,8-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 61973-24-8 1-benzyl-5,7-dimethyl-2,3-dithia-5,7-diaza-bicyclo[2.2.2]octane-6,8-dione 
• 79247-55-5 (1R,5R)-1-Benzyl-3-(4-methoxy-phenyl)-5,6,8-trimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-08-0 (1R,5R)-3-(4-Methoxy-phenyl)-1,6,8-trimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-08-0 3-(4-methoxy-phenyl)-1,6,8-trimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-09-1 3-(4-methoxy-phenyl)-1,5,6,8-tetramethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Two general methods, Method A and Method B in Scheme 19, to synthesize epidithiapiperazinediones, are described.A total synthesis of racemic and optically active gliotoxin (1) and of racemic dehydrogliotoxin (53) was achieved by using Method A, whereas a total synthesis of racemic hyalodendrin (52) was completed by using Method B.