49600-56-8Relevant academic research and scientific papers
Design, synthesis, and evaluation of the anticonvulsant and antidepressant activities of pyrido[2,3-d]pyrimidine derivatives
Zhang, Hong-Jian,Wang, Shi-Ben,Wen, Xiang,Li, Jin-Zi,Quan, Zhe-Shan
, p. 1287 - 1298 (2016)
A series of pyrido[2,3-d]pyrimidine derivatives (4a–4n, 5a–5n, 6, and 7) were designed and synthesized as potential anticonvulsants and antidepressants. Their pharmacological activities were evaluated by maximal electroshock test, forced swimming test, an
Oxidative cyclocondensation of cyclic thio-and selenoureas. 5. 2-Thioxothieno-and 2-thioxopyrido[2,3-d]pyrimidin-4-ones
Mukarramov,Urakov,Shakhidoyatov
, p. 1210 - 1213 (2008/09/19)
A study was carried out on the oxidative cyclocondensation of 2-thioxothieno-and 2-thioxopyrido[2,3-d]pyrimidin-4-ones. The thiophene ring with excess π-electron density facilitates the reaction, while the pyridine ring with diminished π-electron density hinders it. 2-Thioxothieno-[2,3-d] pyridimin-4-ones were converted into previously unreported 7H,13H-[1,2,4] thiadiazolo-[3,2-b:5,4-b′]bis(thieno[2,3-d]pyridimine-7,13-diones).
SYNTHESIS AND PROPERTIES OF 2-AMINO-4,6-DIMETHYLNICOTINIC ACID ARYLAMIDES
Demina, L. M.,Konshin, M. E.
, p. 1179 - 1181 (2007/10/02)
It is shown that on boiling 2-amino-4,6-dimethylnicotinic acid arylamides with triethyl orthoformate in acetic anhydride, derivatives of 3-aryl-5,7-dimethyl-4-oxo-3,4-dihydropyridopyrimidine are formed.The same compounds are obtained by ternary condensation of ethyl 2-amino-4,6-dimethylnicotinate with triethyl orthoformate and arylamines.On reaction with urea or ammonium thiocyanate, the ethyl ester or anilides of 2-amino-4,6-dimethylnicothinic acid are converted to 2,4-dioxo- or 4-oxo-2-thio-pyridopyrimidines respectively.
