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CAS

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496052-56-3

N-(3-fluorophenyl)thiazol-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 496052-56-3 Structure

  • Basic information

    1. Product Name: N-(3-fluorophenyl)thiazol-2-amine
    2. Synonyms: N-(3-fluorophenyl)thiazol-2-amine
    3. CAS NO:496052-56-3
    4. Molecular Formula:
    5. Molecular Weight: 194.232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 496052-56-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-fluorophenyl)thiazol-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-fluorophenyl)thiazol-2-amine(496052-56-3)
    11. EPA Substance Registry System: N-(3-fluorophenyl)thiazol-2-amine(496052-56-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 496052-56-3(Hazardous Substances Data)

496052-56-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 496052-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,6,0,5 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 496052-56:
(8*4)+(7*9)+(6*6)+(5*0)+(4*5)+(3*2)+(2*5)+(1*6)=173
173 % 10 = 3
So 496052-56-3 is a valid CAS Registry Number.

496052-56-3Downstream Products

496052-56-3Relevant articles and documents

Cholinesterase inhibitory activities of N-phenylthiazol-2-amine derivatives and their molecular docking studies

Iqbal, Jamshed,Al-Rashida, Mariya,Babar, Ayesha,Hameed, Abdul,Khan, Muhammad Siraj,Munawar, Munawar Ali,Khan, Ather Farooq

, p. 489 - 496 (2015/07/27)

Alzheimer's disease (AD) is a type of neurodegenerative disorder which is responsible for many cognitive dysfunctions. According to the most accepted cholinergic hypothesis, cholinesterases have a major role in AD symptoms. The use of small molecules as inhibitors is one of the most useful strategies to control AD. In the present work, a series of N-phenylthiazol-2-amine derivatives was screened against acetylcholinesterase (AChE) from Electrophorus electricus and butyrylcholinesterase (BChE) from horse serum by using Ellman's method, using neostigmine and donepezil as reference drugs. Some of the assayed compounds proved to be potent inhibitors for AChE and BChE activity. N-(2,3-dimethylphenyl)thiazol-2-amine, 3j was found to be the most active inhibitor among the series with IC50 value of 0.009 ± 0.002 μM and 0.646 ± 0.012 μM against AChE and BChE, respectively. Molecular docking studies were carried out in order to better understand the ligand binding site interactions.

Palladium-catalyzed n-arylation of 2-aminothiazoles

McGowan, Meredeth A.,Henderson, Jaclyn L.,Buchwald, Stephen L.

supporting information; experimental part, p. 1432 - 1435 (2012/05/05)

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loadi

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