496063-11-7Relevant academic research and scientific papers
METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE
-
, (2018/06/15)
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.
Indanylacetic acids as PPAR-δ activator insulin sensitizers
Wickens, Philip,Zhang, Chengzhi,Ma, Xin,Zhao, Qian,Amatruda, John,Bullock, William,Burns, Michael,Cantin, Louis-David,Chuang, Chih-Yuan,Claus, Thomas,Dai, Miao,Dela Cruz, Fernando,Dickson, David,Ehrgott, Frederick J.,Fan, Dongping,Heald, Sarah,Hentemann, Martin,Iwuagwu, Christiana I.,Johnson, Jeffrey S.,Kumarasinghe, Ellalahewage,Ladner, David,Lavoie, Rico,Liang, Sidney,Livingston, James N.,Lowe, Derek,Magnuson, Steve,Mannelly, Gretchen,Mugge, Ingo,Ogutu, Herbert,Pleasic-Williams, Susan,Schoenleber, Robert W.,Shapiro, Jeff,Shelekhin, Tatiana,Sweet, Laurel,Town, Christopher,Tsutsumi, Manami
, p. 4369 - 4373 (2008/02/12)
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-α and PPAR-δ ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-δ over PPAR-α.
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
-
, (2008/06/13)
This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
