80370-87-2

Basic information

• Product Name: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-
• Synonyms: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-
• CAS NO: 80370-87-2
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 80370-87-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 79 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 388.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.180±0.06 g/cm3(Predicted)
• PKA: 4.56±0.10(Predicted)
• CAS DataBase Reference: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-(80370-87-2)
• EPA Substance Registry System: 1H-INDENE-1-ACETIC ACID, 2,3-DIHYDRO-5-METHOXY-(80370-87-2)

Safety Data

• Hazardous Substances Data: 80370-87-2(Hazardous Substances Data)

Usage

Chemical class

Indene derivatives

Derivative of

Indene-1-acetic acid

Substituents

Methoxy group at the 5th position, dihydro group at the 2nd and 3rd positions

Potential applications

Pharmaceuticals, organic synthesis

Utility

Building block in the synthesis of drugs and biologically active compounds, pharmacological properties, therapeutic effects.

Upstream product

• 66192-25-4 2-bromo-5-methoxybenzyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 33868-91-6 3-(4-methoxyphenyl)glutaric acid 
• 36286-00-7 Indanone-3-acetic acid 
• 162713-88-4 ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate 
• 80370-86-1 (5-Methoxy-indan-1-yl)-acetonitrile 
• 73809-30-0 ethyl (5-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethanoate 
• 80370-85-0 (+/-)-ethyl α-cyano-5'-methoxy-1-indaneacetate 
• 6630-90-6 ethyl 2,2'-(4-methoxybenzal)bis-acetoacetate 
• 5111-70-6 5-methoxy-1-indanone 
• 21779-37-3 (5-methoxy-indan-1-yliden)-acetic acid 

Downstream Products

• 496063-10-6 C₈H₁₁N*C₁₂H₁₄O₃ 
• 496062-48-7 {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid 
• 496062-47-6 ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate 
• 496063-11-7 ethyl ((1S)-5-{2-[2-(4-isopropylphenyl)-5-methyl-1,3-thiazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)acetate 
• 496061-81-5 ethyl 2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)(1,3-oxazol-4-yl)]ethoxy}indanyl)acetate 
• 162713-90-8 <3(1''S),4R>-3-<2'-(5''-methoxy-1''-indanyl)acetyl>-4-(phenylmethyl)-2-oxazolidinone 

Relevant articles and documents

Nickel-Catalyzed Chemo- and Regioselective Benzylarylation of Unactivated Alkenes with o-Bromobenzyl Chlorides

Chemo- and regioselectively nickel-catalyzed reductive benzylarylation of unactivated alkenes with o-bromobenzyl chlorides is disclosed herein, in which electrophiles participate through a single-component double-site approach. Moreover, its utility is underscored by the concise synthesis of bioactive Indane compounds and postreaction functionalizations leading to structurally diverse scaffolds. Preliminary mechanistic investigations suggest a radical chain reaction mechanism.

METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.

INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS

This invention relates to novel indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives whice are useful in the treatment of diseases such sa diabetes, diabetes-related disorders, obesity, hyperlipidemia, and cardiovascular diseases. The invention also relates to intermediates useful in preparation of said carboxylic derivatives and to methods of preparation.