80370-87-2

Usage

Chemical class

Indene derivatives

Derivative of

Indene-1-acetic acid

Substituents

Methoxy group at the 5th position, dihydro group at the 2nd and 3rd positions

Potential applications

Pharmaceuticals, organic synthesis

Utility

Building block in the synthesis of drugs and biologically active compounds, pharmacological properties, therapeutic effects.

Upstream product

• 36286-00-7 Indanone-3-acetic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 73809-30-0 ethyl (5-methoxy-2,3-dihydro-1H-inden-1-ylidene)ethanoate 
• 66192-25-4 2-bromo-5-methoxybenzyl chloride 
• 5111-70-6 5-methoxy-1-indanone 
• 6630-90-6 ethyl 2,2'-(4-methoxybenzal)bis-acetoacetate 
• 33868-91-6 3-(4-methoxyphenyl)glutaric acid 
• 162713-88-4 ethyl (5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoate 
• 80370-86-1 (5-Methoxy-indan-1-yl)-acetonitrile 
• 21779-37-3 (5-methoxy-indan-1-yliden)-acetic acid 
• 80370-85-0 (+/-)-ethyl α-cyano-5'-methoxy-1-indaneacetate 

Downstream Products

• 162713-90-8 <3(1''S),4R>-3-<2'-(5''-methoxy-1''-indanyl)acetyl>-4-(phenylmethyl)-2-oxazolidinone 
• 496063-10-6 C₈H₁₁N*C₁₂H₁₄O₃ 
• 496061-81-5 ethyl 2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)(1,3-oxazol-4-yl)]ethoxy}indanyl)acetate 
• 496063-11-7 ethyl ((1S)-5-{2-[2-(4-isopropylphenyl)-5-methyl-1,3-thiazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)acetate 
• 496062-47-6 ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate 
• 496062-48-7 {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Chemo- and Regioselective Benzylarylation of Unactivated Alkenes with o-Bromobenzyl Chlorides

Chemo- and regioselectively nickel-catalyzed reductive benzylarylation of unactivated alkenes with o-bromobenzyl chlorides is disclosed herein, in which electrophiles participate through a single-component double-site approach. Moreover, its utility is underscored by the concise synthesis of bioactive Indane compounds and postreaction functionalizations leading to structurally diverse scaffolds. Preliminary mechanistic investigations suggest a radical chain reaction mechanism.

METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.

BRIDGED AND FUSED HETEROCYCLIC ANTIDIABETIC COMPOUNDS

This invention provides for certain bridged and fused heterocyclic compounds of the formula (I) or a pharmaceutically acceptable salt, ester solvate or prodrug thereof wherein: L is: (II) and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.

INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS

This invention relates to novel indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives whice are useful in the treatment of diseases such sa diabetes, diabetes-related disorders, obesity, hyperlipidemia, and cardiovascular diseases. The invention also relates to intermediates useful in preparation of said carboxylic derivatives and to methods of preparation.

Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation

This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors

Inhibitors of specific src homology 2 (SH2) domain binding interactions could potentially afford new therapeutic approaches toward a variety of diseases, including several cancers. To date SH2 domain inhibitors have been confined to small phosphotyrosyl (