49618-62-4Relevant academic research and scientific papers
Synthesis of 1,2-Dicyano-3-arylcycl[3.2.2]azines – First 1,2-Dicarbonitriles Based on Cyclazine Heterocycle
Chernyak, Alexander V.,Kalashnikov, Valery V.,Kazachenko, Vladimir P.,Pushkarev, Victor E.,Simakov, Anton O.,Simonov, Sergey V.,Starikov, Andrei S.,Tarakanov, Pavel A.,Tkachev, Valery V.,Tomilova, Larisa G.,Yarkov, Alexander V.,Zhurkin, Fedor E.
, p. 5852 - 5856 (2020)
The first 1,2-dicarbonitriles have been prepared for cyclazine systems. In particular, a synthetic procedure to 1,2-dicyano-3-arylcycl[3.2.2]azines has been developed. Unexpected chlorination of 3-arylcycl[3.2.2]azine-1,2-dicarboxylic acid derivatives by thionyl chloride at 4-position was found, which according to theoretical considerations can proceed by the electrophilic (SEAr) mechanism. The compounds are blue fluorophores in 450–480 nm region with quantum yields in toluene of ca. 30 % for non-chlorinated derivatives, which decrease to 3–4 % for chlorinated ones.
Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
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, (2008/06/13)
The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high association constant to the carrier molecule. The invention also relates to medicaments containing these ligand compounds and to diagnostic kits.
