49619-30-9Relevant academic research and scientific papers
Radical-initiated cyclization as a key step for the synthesis of oxoprotoberberine alkaloids
Lee, Chih-Shone,Yu, Tsung-Ching,Luo, Jian-Wen,Cheng, Yen-Yao,Chuang, Che-Ping
scheme or table, p. 4558 - 4562 (2009/12/03)
The oxoprotoberberine alkaloids 1a-d have been synthesized efficiently from the enamide derivatives 2a-d by a radical-initiated cyclization reaction utilizing n-Bu3SnH/AIBN and CuCl. The enamide derivatives 2a-d were prepared from phenylethylam
Palladium-catalyzed cyclization of 2-heteroyl-1-methylene-1,2,3,4-tetrahydroisoquinolines. Studies on 6-endo- versus 5-exo-trig cyclization
Bombrun, Agnes,Sageot, Olivia
, p. 1057 - 1060 (2007/10/03)
In this paper we report our studies on 6-endo- versus 5-exo-trig cyclizations of 2-hetero-1-methylene-1,2,3,4-tetrahydroisoquinolines. This can be used for the construction of a variety of functionalized five- or six-membered heterocyclic rings.
Isoquinoline frameworks via aryl radical-initiated 1,6-cyclization
Takano,Suzuki,Kijima,Ogasawara
, p. 2315 - 2318 (2007/10/02)
Exclusive 1,6-cyclization occurred to afford isoquinoline frameworks when the enamide and the enamine substrates bearing exo-olefin moiety were treated with tri-n-butyltin hydride in the presence of radical initiator (9a, b → 12a, b; 13a, b → 18a, b), respectively. On the other hand, competitive 1,6- and 1,5-cyclization occurred to give a mixture of isoquinolone and isoindolone frameworks when the enamide substrates bearing endo-olefin moiety were treated under the same conditions (22a, b → 26a, b and 27a, b).
