49619-45-6

Upstream product

• 610-14-0 2-nitrobenzyl chloride 
• 100-51-6 benzyl alcohol 
• 552-16-9 ortho-nitrobenzoic acid 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 872267-40-8 7-hydroxy-2-(2-nitro-phenyl)-3-phenyl-chromen-4-one 
• 31042-59-8 phenyl 2-nitrobenzoate 
• 65671-94-5 7-methoxy-2-(2-nitro-phenyl)-3-phenyl-chromen-4-one 
• 65671-96-7 2-(2-amino-phenyl)-7-methoxy-3-phenyl-chromen-4-one 

Relevant academic research and scientific papers

Cu-MOF: An efficient heterogeneous catalyst for the synthesis of symmetric anhydrides: Via the C-H bond activation of aldehydes

In this paper, an efficient and straightforward synthetic approach for the preparation of a number of symmetric carboxylic anhydrides was reported using Cu2(BDC)2(DABCO) as an efficient heterogeneous catalyst via the C-H bond activation of aldehydes with excellent yields and simple work up. This C-H bond activation reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The Cu-MOF catalyst was recycled and reused four times without any loss of catalytic activity.

Efficient and convenient synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by phase transfer catalysis

An efficient and convenient procedure for the synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by PEG-1000 phase transfer catalysis has been developed. The reactions proceeded under mild and solvent-free conditions to provide the carboxylic anhydrides in good to excellent yields. The product can be isolated by a simple extraction with organic solvent, and the catalyst system can be recycled or reused without any significant loss of catalytic activity.

A mild, clean, and simple synthesis of symmetrical carboxylic anhydrides from carboxylic acides using a polymer supported tosyl chloride

The use of polymeric reagents simplifies routine acylation of carboxylic acid because it eliminates the traditional purification. We describe the use of readily available cross-linked poly(4-vinylpyridine) supported tosyl chloride, [P4VP].TsCl, in the suspended solution phase synthesis of symmetrical anhydrides from carboxylic acids in the presence of K2CO3 in high yields and purity. The products can be obtained by filtration and evaporation of the solvent.

2,6-Dimethyl-4-nitrobenzoic anhydride (DMNBA): An effective coupling reagent for the synthesis of carboxylic esters and lactones

Various carboxylic esters are obtained at room temperature in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols using 2,6-dimethyl-4-nitrobenzoic anhydride with triethylamine by the promotion of 4-(dimethylamino)pyridine. The efficiency of the esterification is compared to those of other dehydrations using substituted benzoic anhydrides as coupling reagents. This method was successfully applied to the synthesis of threo-aleuritic acid lactone and the desired 17-membered ring compound was prepared in high yield at room temperature from the corresponding free trihydroxycarboxylic acid using 2,6-dimethyl-4-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine.

Mild and efficient synthesis of carboxylic acid anhydrides from carboxylic acids and triazine coupling reagents

Anhydrides of carboxylic acids were obtained in 53%-95% yield by treatment of appropriate carboxylic acids with 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) or 2,4-dichloro-6-methoxy-1,3,5-triazine (DCMT) in the presence of N-methylmorpholine. It has been proved that synthesis proceeds via triazine active esters 3a,b, which are able to acylate carboxylate anion but not less nucleophilic carboxylic acid.

Dabco/SOCl2, mild, and convenient reagent for the preparation of symmetrical carboxylic acid anhydrides

Various types of carboxylic acids undergo rapid dehydration with 1,4-diazabicyclo[2.2.2]octane, dabco / thionyl chloride, under mild reaction conditions to afford symmetrical acid anhydrides in high isolated yields.

Synthesis of anhydrides from acyl chlorides under ultrasound condition

A convenient and general method for the synthesis of symmetrical anhydrides under ultrasound conditions is described.

Solid-liquid phase transfer and cobalt or palladium complex catalyzed synthesis of anhydrides from acyl chlorides

Acyl chloride can efficiently be converted into anhydride under solid liquid phase transfer catalysis by using bis(triphenylphosphine)cobalt dichloride or bis (triphenylphospine)palladium dichloride as catalyst.