49622-09-5Relevant academic research and scientific papers
N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases
Berlicki, Lukasz,Bochno, Marta,Grabowiecka, Agnieszka,Bialas, Arkadiusz,Kosikowska, Paulina,Kafarski, Pawel
, p. 1937 - 1945 (2012/10/18)
Small unextended molecules based on the diamidophosphate structure with a covalent carbon-to-phosphorus bond to improve hydrolytic stability were developed as a novel group of inhibitors to control microbial urea decomposition. Applying a structure-based
A convenient one-pot synthesis of β-trifluoromethyl) allylaminophosphonic and benzylaminophosphonic acids
Cal, Dariusz,Bartnik, Romuald
experimental part, p. 1054 - 1064 (2009/12/07)
The reductive condensation of aminoalkylphosphonic acids with*β-chloro- or*β-ethylthio-(*β- trifluoromethyl)acroleins leads to secondary (trifluoromethyl) allylaminophosphonic acids in moderate to good yields. The method appears to be useful for the prepa
Process for the preparation of N-phosphonomethylglycine and derivatives thereof
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Page/Page column 30, (2010/02/11)
N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.
NOVEL UNSYMMETRICAL N,N-BIS(METHYLENE)BIPHOSPHONIC ACIDS OF α,ω-DIAMINES. PREPARATION AND CHARACTERIZATION OF BIS(METHYLENE)>-BIPHOSPHONIC ACID AND BIS(METHYLENE)>-BIPHOSPHONIC ACID
Redmore, Derek,Dhawan, Balram
, p. 233 - 238 (2007/10/02)
Reaction of ethylenediamine with phosphorous acid and formaldehyde in molar ratio 1:2:2 gives bis(methylene)>biphosphonic acid (2a) as the major product.Similarly, reaction of hexamethylenediamine with phosphorous acid and formaldehyde in molar ratio 1:2:2 yields bis(methylene)>biphosphonic acid (2b) which is isolated either as bis(methylene>biphosphonic acid (3b) or as bis(methylene)>biphosphonic acid (4b).Removal of the carbobenzoxy group with HBr 3b or the benzoyl group with HCl from 4b gives pure bis(methylene)>biphosphonic acid (2b).All compounds were characterized by 13C NMR, 31P NMR and elemental analysis.
